Assay Detail
Functional
CHEMBL821155
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Inhibitory activity against human W1L2 cell growth
15
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WIL2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.59 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355543 | — | — | 2 | 7.13 |
| CHEMBL170933 | — | — | 2 | 7.03 |
| CHEMBL170975 | — | — | 1 | 6.82 |
| CHEMBL170789 | — | — | 1 | 6.82 |
| CHEMBL349432 | — | — | 2 | 6.72 |
| CHEMBL354785 | — | — | 1 | 6.66 |
| CHEMBL168970 | — | — | 1 | 6.66 |
| CHEMBL353066 | — | — | 1 | 6.64 |
| CHEMBL367732 | — | — | 1 | 6.55 |
| CHEMBL263325 | — | — | 1 | 6.05 |
| CHEMBL168553 | — | — | 1 | 5.85 |
| CHEMBL169540 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355543 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL355543 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL170933 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL170975 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL170789 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL170933 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL349432 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL354785 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL168970 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL353066 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL367732 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL349432 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL263325 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL168553 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL169540 | — | IC50 | = | 2400.0 | nM | 5.62 |