Assay Detail
Binding
CHEMBL821387
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dissociation constant obtained by inhibition of Wild-type protease
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.97 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 10.21 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 10.21 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 9.85 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 9.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | Ki | = | 0.062 | nM | 10.21 |
| CHEMBL163 | RITONAVIR | Ki | = | 0.062 | nM | 10.21 |
| CHEMBL584 | NELFINAVIR | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL5483011 | INDINAVIR | Ki | = | 0.24 | nM | 9.62 |