Assay Detail
Binding
CHEMBL821404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity assay fluomicrospheres.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 28 | 8.85 | 10.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57040 | — | — | 1 | 10.25 |
| CHEMBL298655 | — | — | 1 | 10.10 |
| CHEMBL293601 | — | — | 1 | 10.05 |
| CHEMBL59562 | — | — | 1 | 9.80 |
| CHEMBL58328 | — | — | 1 | 9.60 |
| CHEMBL298589 | — | — | 1 | 9.60 |
| CHEMBL57191 | — | — | 1 | 9.59 |
| CHEMBL293588 | — | — | 1 | 9.52 |
| CHEMBL58713 | — | — | 1 | 9.47 |
| CHEMBL57881 | — | — | 1 | 9.42 |
| CHEMBL57886 | — | — | 1 | 9.25 |
| CHEMBL58675 | — | — | 1 | 9.11 |
| CHEMBL57192 | — | — | 1 | 9.11 |
| CHEMBL58790 | — | — | 1 | 9.11 |
| CHEMBL262194 | — | — | 1 | 9.07 |
| CHEMBL292663 | — | — | 1 | 9.07 |
| CHEMBL916 | TIROFIBAN | 4.0 | 1 | 8.72 |
| CHEMBL59020 | — | — | 1 | 8.66 |
| CHEMBL48371 | — | — | 1 | 8.35 |
| CHEMBL57134 | — | — | 1 | 8.17 |
| CHEMBL444573 | — | — | 1 | 8.05 |
| CHEMBL58152 | — | — | 1 | 8.01 |
| CHEMBL61353 | — | — | 1 | 7.92 |
| CHEMBL32960 | — | — | 1 | 7.89 |
| CHEMBL57094 | — | — | 1 | 7.82 |
| CHEMBL441438 | — | — | 1 | 7.68 |
| CHEMBL300097 | — | — | 1 | 7.34 |
| CHEMBL58618 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57040 | — | Kd | = | 0.056 | nM | 10.25 |
| CHEMBL298655 | — | Kd | = | 0.08 | nM | 10.10 |
| CHEMBL293601 | — | Kd | = | 0.09 | nM | 10.05 |
| CHEMBL59562 | — | Kd | = | 0.16 | nM | 9.80 |
| CHEMBL58328 | — | Kd | = | 0.25 | nM | 9.60 |
| CHEMBL298589 | — | Kd | = | 0.25 | nM | 9.60 |
| CHEMBL57191 | — | Kd | = | 0.26 | nM | 9.59 |
| CHEMBL293588 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL58713 | — | Kd | = | 0.34 | nM | 9.47 |
| CHEMBL57881 | — | Kd | = | 0.38 | nM | 9.42 |
| CHEMBL57886 | — | Kd | = | 0.56 | nM | 9.25 |
| CHEMBL58675 | — | Kd | = | 0.77 | nM | 9.11 |
| CHEMBL57192 | — | Kd | = | 0.78 | nM | 9.11 |
| CHEMBL58790 | — | Kd | = | 0.78 | nM | 9.11 |
| CHEMBL262194 | — | Kd | = | 0.85 | nM | 9.07 |
| CHEMBL292663 | — | Kd | = | 0.86 | nM | 9.07 |
| CHEMBL916 | TIROFIBAN | Kd | = | 1.9 | nM | 8.72 |
| CHEMBL59020 | — | Kd | = | 2.2 | nM | 8.66 |
| CHEMBL48371 | — | Kd | = | 4.5 | nM | 8.35 |
| CHEMBL57134 | — | Kd | = | 6.7 | nM | 8.17 |
| CHEMBL444573 | — | Kd | = | 9.0 | nM | 8.05 |
| CHEMBL58152 | — | Kd | = | 9.7 | nM | 8.01 |
| CHEMBL61353 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL32960 | — | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL57094 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL441438 | — | Kd | = | 21.0 | nM | 7.68 |
| CHEMBL300097 | — | Kd | = | 46.0 | nM | 7.34 |
| CHEMBL58618 | — | Kd | = | 64.0 | nM | 7.19 |