Assay Detail
Binding
CHEMBL821472
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against human recombinant Aldose reductase in streptozotocin diabetic rat at 50 mg/kg
1
Total Activities
1
Compounds Tested
1
Activity Types
1
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.85 | 6.85 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| DOSE | DOSE | 50.0 | mg.kg-1 | — |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | IC50 | = | 140.0 | nM | 6.85 |