Assay Detail
Binding
CHEMBL821497
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cAMP phosphodiesterase preparation from bovine heart at a substrate concentration of 0.14 uM
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and enzymatic and inotropic activity of some new 8-substituted and 6,8-disubstituted derivatives of adenosine cyclic 3',5'-monophosphate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 65 | 4.64 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3142460 | — | — | 1 | 5.51 |
| CHEMBL3142490 | — | — | 1 | 5.44 |
| CHEMBL3142454 | — | — | 1 | 5.43 |
| CHEMBL3142456 | — | — | 1 | 5.25 |
| CHEMBL3142451 | — | — | 1 | 5.25 |
| CHEMBL3142478 | — | — | 1 | 5.25 |
| CHEMBL1626177 | — | — | 1 | 5.11 |
| CHEMBL3142502 | — | — | 1 | 5.11 |
| CHEMBL3142477 | — | — | 1 | 5.08 |
| CHEMBL3142484 | — | — | 1 | 5.08 |
| CHEMBL3142430 | — | — | 1 | 5.04 |
| CHEMBL3142464 | — | — | 1 | 5.00 |
| CHEMBL3142463 | — | — | 1 | 4.96 |
| CHEMBL3142469 | — | — | 1 | 4.96 |
| CHEMBL3142480 | — | — | 1 | 4.92 |
| CHEMBL3142472 | — | — | 1 | 4.89 |
| CHEMBL3142498 | — | — | 1 | 4.89 |
| CHEMBL3142471 | — | — | 1 | 4.85 |
| CHEMBL3142470 | — | — | 1 | 4.77 |
| CHEMBL3142495 | — | — | 1 | 4.75 |
| CHEMBL3142467 | — | — | 1 | 4.72 |
| CHEMBL3142491 | — | — | 1 | 4.68 |
| CHEMBL230552 | — | — | 1 | 4.66 |
| CHEMBL2107085 | TOCLADESINE | 2.0 | 1 | 4.66 |
| CHEMBL3306988 | — | — | 1 | 4.62 |
| CHEMBL3142493 | — | — | 1 | 4.57 |
| CHEMBL3142496 | — | — | 1 | 4.54 |
| CHEMBL3142434 | — | — | 1 | 4.54 |
| CHEMBL3142448 | — | — | 1 | 4.50 |
| CHEMBL3142446 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3142460 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3142490 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3142454 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3142456 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3142451 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3142478 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1626177 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL3142502 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL3142477 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3142484 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3142430 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3142464 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3142463 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3142469 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3142480 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3142472 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3142498 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3142471 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3142470 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3142495 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3142467 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3142491 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL230552 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2107085 | TOCLADESINE | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3306988 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3142493 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3142434 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3142496 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3142448 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3142446 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3142483 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3142466 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3142503 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3142465 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3142444 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3142452 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3142462 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3142486 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3142438 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3142439 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3142479 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL3142447 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL3142453 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL3142492 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL3142440 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL3142449 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL3142488 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL3142475 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL3142489 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL3142435 | — | IC50 | = | 77000.0 | nM | 4.11 |