Assay Detail
Binding
CHEMBL821513
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In vivo inhibition of cyclic AMP phosphodiesterase from human platelets
87
Total Activities
87
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 87 | 7.12 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326891 | — | — | 1 | 9.03 |
| CHEMBL108876 | — | — | 1 | 9.00 |
| CHEMBL321600 | — | — | 1 | 9.00 |
| CHEMBL109149 | — | — | 1 | 8.96 |
| CHEMBL324011 | — | — | 1 | 8.89 |
| CHEMBL107651 | — | — | 1 | 8.84 |
| CHEMBL110484 | — | — | 1 | 8.84 |
| CHEMBL106922 | — | — | 1 | 8.82 |
| CHEMBL106201 | — | — | 1 | 8.73 |
| CHEMBL322596 | — | — | 1 | 8.70 |
| CHEMBL110172 | — | — | 1 | 8.66 |
| CHEMBL110350 | — | — | 1 | 8.57 |
| CHEMBL108914 | — | — | 1 | 8.49 |
| CHEMBL109062 | — | — | 1 | 8.44 |
| CHEMBL107034 | — | — | 1 | 8.39 |
| CHEMBL110734 | — | — | 1 | 8.35 |
| CHEMBL109096 | — | — | 1 | 8.34 |
| CHEMBL108741 | — | — | 1 | 8.31 |
| CHEMBL110374 | — | — | 1 | 8.30 |
| CHEMBL106141 | — | — | 1 | 8.27 |
| CHEMBL110087 | — | — | 1 | 8.25 |
| CHEMBL320430 | — | — | 1 | 8.23 |
| CHEMBL110338 | — | — | 1 | 8.22 |
| CHEMBL107939 | — | — | 1 | 8.19 |
| CHEMBL419368 | — | — | 1 | 8.04 |
| CHEMBL105793 | — | — | 1 | 8.00 |
| CHEMBL110675 | — | — | 1 | 7.96 |
| CHEMBL109058 | — | — | 1 | 7.92 |
| CHEMBL262661 | — | — | 1 | 7.92 |
| CHEMBL320180 | — | — | 1 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326891 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL108876 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL321600 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL109149 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL324011 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL107651 | — | IC50 | = | 1.45 | nM | 8.84 |
| CHEMBL110484 | — | IC50 | = | 1.45 | nM | 8.84 |
| CHEMBL106922 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL106201 | — | IC50 | = | 1.85 | nM | 8.73 |
| CHEMBL322596 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL110172 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL110350 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL108914 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL109062 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL107034 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL110734 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL109096 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL108741 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL110374 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL106141 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL110087 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL320430 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL110338 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL107939 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL419368 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL105793 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL110675 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL109058 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL262661 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL320180 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL108703 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL110450 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL323400 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL110483 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL323174 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL107261 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL108152 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL107937 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL110787 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL430684 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL108913 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL106498 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL432398 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL323494 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL322946 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL109057 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL108365 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL110218 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL108752 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL440593 | CI-930 | IC50 | = | 150.0 | nM | 6.82 |