Assay Detail
Binding
CHEMBL821536
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Tested for inhibition of protein tyrosine kinase c-Src phosphorylation in intact cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.84 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105436 | — | — | 1 | 6.70 |
| CHEMBL424375 | — | — | 1 | 6.30 |
| CHEMBL173453 | — | — | 1 | 6.16 |
| CHEMBL172973 | — | — | 1 | 5.48 |
| CHEMBL169757 | — | — | 1 | 5.46 |
| CHEMBL175409 | — | — | 1 | 5.41 |
| CHEMBL176702 | — | — | 1 | 5.40 |
| CHEMBL173478 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105436 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL424375 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL173453 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL172973 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL169757 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL175409 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL176702 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL173478 | — | IC50 | > | 5000.0 | nM | - |