Assay Detail
Functional
CHEMBL821608
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In Vitro cytotoxicity against human colon cancer cell line (WiDr)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.10 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 7.85 |
| CHEMBL289665 | — | — | 1 | 7.80 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.77 |
| CHEMBL445883 | — | — | 1 | 7.68 |
| CHEMBL44044 | — | — | 1 | 7.64 |
| CHEMBL297811 | — | — | 1 | 7.64 |
| CHEMBL296862 | — | — | 1 | 7.52 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.25 |
| CHEMBL288053 | — | — | 1 | 6.87 |
| CHEMBL41652 | — | — | 1 | 6.38 |
| CHEMBL297040 | — | — | 1 | 5.50 |
| CHEMBL290652 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL289665 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL445883 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL44044 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL297811 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL296862 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL288053 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL41652 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL297040 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL290652 | — | IC50 | = | 5339.0 | nM | 5.27 |