Assay Detail
Functional
CHEMBL821636
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In Vitro cytotoxicity against human ovarian cancer cell line (SK-OV-3)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.03 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 7.96 |
| CHEMBL289665 | — | — | 1 | 7.85 |
| CHEMBL445883 | — | — | 1 | 7.72 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.70 |
| CHEMBL297811 | — | — | 1 | 7.58 |
| CHEMBL44044 | — | — | 1 | 7.55 |
| CHEMBL296862 | — | — | 1 | 7.50 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.32 |
| CHEMBL288053 | — | — | 1 | 6.85 |
| CHEMBL41652 | — | — | 1 | 6.27 |
| CHEMBL297040 | — | — | 1 | 5.06 |
| CHEMBL290652 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL289665 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL445883 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL297811 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL44044 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL296862 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL288053 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL41652 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL297040 | — | IC50 | = | 8629.0 | nM | 5.06 |
| CHEMBL290652 | — | IC50 | = | 10585.0 | nM | 4.97 |