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Assay Detail

CHEMBL821730

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against calpain.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Calpain-1 catalytic subunit (CHEMBL3891)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Protease inhibitors: current status and future prospects.
Leung D, Abbenante G, Fairlie DP.
J Med Chem (2000) 43 : 305 -341
PubMed 10669559 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 6.78 7.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL115073 1 7.55
CHEMBL92708 CALPEPTIN 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL115073 IC50 = 28.0 nM 7.55
CHEMBL92708 CALPEPTIN IC50 = 1000.0 nM 6.00