Assay Detail
Functional
CHEMBL821855
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against melatonin-induced pigment aggregation by 50% in Xenopus laevis dermal melanophore cell line
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | frog |
| Cell Type | Melanophore |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.61 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286615 | LUZINDOLE | — | 1 | 5.68 |
| CHEMBL538394 | — | — | 1 | 5.47 |
| CHEMBL140728 | — | — | 1 | 5.22 |
| CHEMBL127827 | — | — | 1 | 5.19 |
| CHEMBL139873 | — | — | 1 | 5.00 |
| CHEMBL38520 | — | — | 1 | 4.96 |
| CHEMBL143877 | — | — | 1 | 4.96 |
| CHEMBL141944 | — | — | 1 | 4.85 |
| CHEMBL348238 | — | — | 1 | 4.85 |
| CHEMBL140627 | — | — | 1 | 4.82 |
| CHEMBL143158 | — | — | 1 | 4.77 |
| CHEMBL343878 | — | — | 1 | 4.75 |
| CHEMBL38962 | — | — | 1 | 4.50 |
| CHEMBL141011 | — | — | 1 | 4.48 |
| CHEMBL422118 | — | — | 1 | 4.46 |
| CHEMBL291120 | — | — | 1 | 4.41 |
| CHEMBL356536 | — | — | 1 | 4.41 |
| CHEMBL139832 | — | — | 1 | 4.39 |
| CHEMBL344521 | — | — | 1 | 4.38 |
| CHEMBL143322 | — | — | 1 | 4.38 |
| CHEMBL289370 | — | — | 1 | 4.37 |
| CHEMBL143547 | — | — | 1 | 4.37 |
| CHEMBL142631 | — | — | 1 | 4.36 |
| CHEMBL346408 | — | — | 1 | 4.34 |
| CHEMBL424297 | — | — | 1 | 4.32 |
| CHEMBL139839 | — | — | 1 | 4.30 |
| CHEMBL435080 | — | — | 1 | 4.28 |
| CHEMBL358354 | — | — | 1 | 4.27 |
| CHEMBL359381 | — | — | 1 | 4.25 |
| CHEMBL357127 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286615 | LUZINDOLE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL538394 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL140728 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL127827 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL139873 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL38520 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL143877 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL141944 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL348238 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL140627 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL143158 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL343878 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL38962 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL141011 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL422118 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL356536 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL291120 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL139832 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL344521 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL143322 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL289370 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL143547 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL142631 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL346408 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL424297 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL139839 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL435080 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL358354 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL359381 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL357127 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL143677 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL41973 | — | IC50 | = | 64000.0 | nM | 4.19 |