Assay Detail
Functional
CHEMBL821856
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunits
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Target
GABA A receptor alpha-1/beta-1/gamma-2 (CHEMBL2111392) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.00 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526 | PROPOFOL | 4.0 | 1 | 5.10 |
| CHEMBL298951 | — | — | 1 | 5.05 |
| CHEMBL292402 | — | — | 1 | 5.00 |
| CHEMBL54497 | — | — | 1 | 4.92 |
| CHEMBL53267 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526 | PROPOFOL | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL298951 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL292402 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL54497 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL53267 | — | EC50 | = | 12000.0 | nM | 4.92 |