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Assay Detail

CHEMBL821897

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Binding
Inhibitory activity against histone deacetylase (HDAC) from partially purified extracts of Eimeria tenella protozoal cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cryptosporidium parvum
Confidence 9 — Direct single protein target
Curated By Expert

Target

Histone deacetylase (CHEMBL4740)
Type SINGLE PROTEIN
Organism Cryptosporidium parvum

Publication

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.
Colletti SL, Myers RW, Darkin-Rattray SJ, Gurnett AM, Dulski PM, Galuska S, Allocco JJ, Ayer MB, Li C, Lim J, Crumley TM, Cannova C, Schmatz DM, Wyvratt MJ, Fisher MH, Meinke PT.
Bioorg Med Chem Lett (2001) 11 : 107 -111
PubMed 11206438 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.45 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1793816 1 9.10
CHEMBL1793812 1 9.00
CHEMBL1793810 1 9.00
CHEMBL1793822 1 8.40
CHEMBL1793811 1 8.40
CHEMBL1793827 1 7.52
CHEMBL1793944 1 6.96
CHEMBL1793815 1 6.68
CHEMBL1793943 1 6.68
CHEMBL1793814 1 6.68
CHEMBL1793807 1 6.52
CHEMBL1793809 1 6.07
CHEMBL1793806 1 5.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1793816 IC50 = 0.8 nM 9.10
CHEMBL1793812 IC50 = 1.0 nM 9.00
CHEMBL1793810 IC50 = 1.0 nM 9.00
CHEMBL1793822 IC50 = 4.0 nM 8.40
CHEMBL1793811 IC50 = 4.0 nM 8.40
CHEMBL1793827 IC50 = 30.0 nM 7.52
CHEMBL1793944 IC50 = 110.0 nM 6.96
CHEMBL1793815 IC50 = 210.0 nM 6.68
CHEMBL1793943 IC50 = 210.0 nM 6.68
CHEMBL1793814 IC50 = 210.0 nM 6.68
CHEMBL1793807 IC50 = 300.0 nM 6.52
CHEMBL1793809 IC50 = 850.0 nM 6.07
CHEMBL1793806 IC50 = 1500.0 nM 5.82