Assay Detail
Binding
CHEMBL821898
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Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cells
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.55 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1793811 | — | — | 1 | 9.70 |
| CHEMBL1793822 | — | — | 1 | 9.52 |
| CHEMBL1793816 | — | — | 1 | 9.40 |
| CHEMBL1793823 | — | — | 1 | 9.00 |
| CHEMBL1793810 | — | — | 1 | 9.00 |
| CHEMBL1793947 | — | — | 1 | 9.00 |
| CHEMBL1793938 | — | — | 1 | 8.70 |
| CHEMBL1793945 | — | — | 1 | 8.52 |
| CHEMBL1793941 | — | — | 1 | 8.30 |
| CHEMBL1793937 | — | — | 1 | 8.22 |
| CHEMBL1793819 | — | — | 1 | 8.15 |
| CHEMBL1793827 | — | — | 1 | 7.82 |
| CHEMBL1793820 | — | — | 1 | 7.75 |
| CHEMBL1793824 | — | — | 1 | 7.52 |
| CHEMBL1793825 | — | — | 1 | 7.41 |
| CHEMBL1793813 | — | — | 1 | 7.22 |
| CHEMBL1793807 | — | — | 1 | 7.21 |
| CHEMBL1793944 | — | — | 1 | 7.14 |
| CHEMBL1793936 | — | — | 1 | 7.13 |
| CHEMBL1793826 | — | — | 1 | 6.96 |
| CHEMBL1793939 | — | — | 1 | 6.96 |
| CHEMBL1793808 | — | — | 1 | 6.84 |
| CHEMBL1793818 | — | — | 1 | 6.75 |
| CHEMBL1793946 | — | — | 1 | 6.63 |
| CHEMBL1793828 | — | — | 1 | 6.55 |
| CHEMBL1793940 | — | — | 1 | 6.49 |
| CHEMBL1793809 | — | — | 1 | 6.35 |
| CHEMBL1793942 | — | — | 1 | 6.16 |
| CHEMBL1793821 | — | — | 1 | 6.07 |
| CHEMBL1793806 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1793811 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1793822 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1793816 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1793823 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1793810 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1793947 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1793938 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1793945 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1793941 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1793937 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1793819 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1793827 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1793820 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1793824 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1793825 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1793813 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1793807 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1793944 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1793936 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1793826 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1793939 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1793808 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL1793818 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1793946 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL1793828 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL1793940 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL1793809 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1793942 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1793821 | — | IC50 | = | 848.0 | nM | 6.07 |
| CHEMBL1793806 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL1793817 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1793812 | — | IC50 | < | 0.1 | nM | - |