Assay Detail
Functional
CHEMBL821923
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Inhibition of high affinity choline uptake at concentration of 1 uM
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium- and chloride-dependent creatine transporter 1 (CHEMBL3814) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.08 | 4.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57283 | — | — | 1 | 4.08 |
| CHEMBL57055 | CATECHOLINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57283 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL57055 | CATECHOLINE | IC50 | = | 221000.0 | nM | - |