Assay Detail
Binding
CHEMBL822181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C delta
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.90 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | 2.0 | 1 | 9.10 |
| CHEMBL6453 | — | — | 1 | 6.94 |
| CHEMBL173348 | — | — | 1 | 6.82 |
| CHEMBL368720 | — | — | 1 | 5.86 |
| CHEMBL440201 | — | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL6453 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL173348 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL368720 | — | Ki | = | 1370.0 | nM | 5.86 |
| CHEMBL440201 | — | Ki | = | 1630.0 | nM | 5.79 |