Assay Detail
Binding
CHEMBL822190
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against deletion mutant of MT1-MMP lacking the transmembrane domain (deltaMT1)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.09 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.74 |
| CHEMBL16520 | RO-319790 | — | 1 | 8.72 |
| CHEMBL20154 | — | — | 1 | 8.72 |
| CHEMBL279078 | — | — | 1 | 8.68 |
| CHEMBL281371 | — | — | 1 | 8.64 |
| CHEMBL20043 | — | — | 1 | 8.60 |
| CHEMBL279786 | BATIMASTAT | 2.0 | 1 | 8.52 |
| CHEMBL432842 | — | — | 1 | 8.07 |
| CHEMBL19932 | — | — | 1 | 7.89 |
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 7.87 |
| CHEMBL433426 | — | — | 1 | 7.75 |
| CHEMBL279964 | — | — | 1 | 7.71 |
| CHEMBL19843 | — | — | 1 | 7.25 |
| CHEMBL433816 | — | — | 1 | 7.14 |
| CHEMBL19623 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | IC50 | = | 1.82 | nM | 8.74 |
| CHEMBL16520 | RO-319790 | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL20154 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL279078 | — | IC50 | = | 2.08 | nM | 8.68 |
| CHEMBL281371 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL20043 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL279786 | BATIMASTAT | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL432842 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL19932 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL19611 | ILOMASTAT | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL433426 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL279964 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL19843 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL433816 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL19623 | — | IC50 | = | 105.0 | nM | 6.98 |