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Assay Detail

CHEMBL822229

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of papain.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Carica papaya
Confidence 9 — Direct single protein target
Curated By Expert

Target

Papain (CHEMBL4779)
Type SINGLE PROTEIN
Organism Carica papaya

Publication

Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases.
Wieczerzak E, Drabik P, Łankiewicz L, Ołdziej S, Grzonka Z, Abrahamson M, Grubb A, Brömme D.
J Med Chem (2002) 45 : 4202 -4211
PubMed 12213061 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 8.35 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2028920 1 10.00
CHEMBL2028910 1 9.92
CHEMBL2028912 1 9.55
CHEMBL2028909 1 9.25
CHEMBL2028921 1 9.24
CHEMBL2028907 1 9.11
CHEMBL2028908 1 9.11
CHEMBL2028911 1 9.02
CHEMBL2028919 1 8.87
CHEMBL3143135 1 8.17
CHEMBL2028906 1 7.77
CHEMBL2028925 1 7.70
CHEMBL2028924 1 7.68
CHEMBL3143130 1 7.62
CHEMBL2028923 1 7.55
CHEMBL2028922 1 7.52
CHEMBL2028926 1 7.50
CHEMBL2028918 1 7.23
CHEMBL2028917 1 7.21
CHEMBL2028913 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2028920 Ki = 0.1 nM 10.00
CHEMBL2028910 Ki = 0.12 nM 9.92
CHEMBL2028912 Ki = 0.28 nM 9.55
CHEMBL2028909 Ki = 0.56 nM 9.25
CHEMBL2028921 Ki = 0.58 nM 9.24
CHEMBL2028907 Ki = 0.77 nM 9.11
CHEMBL2028908 Ki = 0.78 nM 9.11
CHEMBL2028911 Ki = 0.95 nM 9.02
CHEMBL2028919 Ki = 1.35 nM 8.87
CHEMBL3143135 Ki = 6.7 nM 8.17
CHEMBL2028906 Ki = 17.0 nM 7.77
CHEMBL2028925 Ki = 20.0 nM 7.70
CHEMBL2028924 Ki = 21.0 nM 7.68
CHEMBL3143130 Ki = 24.0 nM 7.62
CHEMBL2028923 Ki = 28.0 nM 7.55
CHEMBL2028922 Ki = 30.0 nM 7.52
CHEMBL2028926 Ki = 32.0 nM 7.50
CHEMBL2028918 Ki = 59.0 nM 7.23
CHEMBL2028917 Ki = 61.0 nM 7.21
CHEMBL2028913 Ki = 100.0 nM 7.00