Assay Detail
Functional
CHEMBL822285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to reduce proliferation of human splenic B-lymphoblastoid (Wil2-NS) cell line by 50% as determined by the MTT method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WIL2-NS |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.74 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353101 | — | — | 1 | 9.00 |
| CHEMBL355741 | — | — | 1 | 8.00 |
| CHEMBL366728 | — | — | 1 | 7.70 |
| CHEMBL436051 | — | — | 1 | 7.70 |
| CHEMBL168653 | — | — | 1 | 7.52 |
| CHEMBL440012 | — | — | 1 | 7.52 |
| CHEMBL151423 | — | — | 1 | 7.30 |
| CHEMBL169393 | — | — | 1 | 7.22 |
| CHEMBL355213 | — | — | 1 | 7.05 |
| CHEMBL353522 | — | — | 1 | 6.00 |
| CHEMBL169305 | — | — | 1 | 5.85 |
| CHEMBL168964 | — | — | 1 | 5.70 |
| CHEMBL170164 | — | — | 1 | 5.68 |
| CHEMBL168693 | — | — | 1 | 5.68 |
| CHEMBL169995 | — | — | 1 | 5.60 |
| CHEMBL354182 | — | — | 1 | 5.60 |
| CHEMBL354952 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353101 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL355741 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL366728 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL436051 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL168653 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL440012 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL151423 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL169393 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL355213 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL353522 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL169305 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL168964 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL170164 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL168693 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL169995 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL354182 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL354952 | — | IC50 | = | 3100.0 | nM | 5.51 |