Assay Detail
Functional
CHEMBL822315
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Compound was tested for functional response of human metabotropic glutamate receptor mGluR1-alpha expressed in AV-12 cells by measuring inhibitory concentration towards quisqualate induced PI hydrolysis
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | AV12 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.68 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313124 | — | — | 1 | 5.22 |
| CHEMBL94631 | — | — | 3 | 5.06 |
| CHEMBL94990 | — | — | 1 | 4.24 |
| CHEMBL329905 | — | — | 1 | 4.14 |
| CHEMBL313938 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313124 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL94631 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL94631 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL94990 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL329905 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL94631 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL313938 | — | IC50 | = | 214000.0 | nM | - |