Assay Detail
Functional
CHEMBL822489
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Inhibitory concentration against murine SCCVII cell line under aerobic condition
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | SCC-7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.89 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301335 | — | — | 1 | 5.68 |
| CHEMBL50823 | — | — | 1 | 5.55 |
| CHEMBL53696 | — | — | 1 | 5.09 |
| CHEMBL50512 | — | — | 1 | 4.91 |
| CHEMBL52475 | — | — | 1 | 4.81 |
| CHEMBL53447 | — | — | 1 | 4.75 |
| CHEMBL299182 | — | — | 1 | 4.68 |
| CHEMBL53017 | — | — | 1 | 4.62 |
| CHEMBL53776 | — | — | 1 | 4.62 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 4.14 |
| CHEMBL53592 | — | — | 1 | - |
| CHEMBL301391 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301335 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL50823 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL53696 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL50512 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL52475 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL53447 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL299182 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL53017 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL53776 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 71700.0 | nM | 4.14 |
| CHEMBL53592 | — | IC50 | = | 217000.0 | nM | - |
| CHEMBL301391 | — | IC50 | = | 288000.0 | nM | - |