Assay Detail
Functional
CHEMBL822565
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Effective concentration for stimulation of adenylyl cyclase activity in CHO-beta3 AR expressing cell membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carboxyl-promoted enhancement of selectivity for the 3 adrenergic receptor. Negative charge of the sulfonic acid BMS-187413 introduces-3 binding selectivity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.16 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38538 | — | — | 1 | 7.22 |
| CHEMBL38486 | — | — | 1 | 6.38 |
| CHEMBL40966 | — | — | 1 | 6.21 |
| CHEMBL284782 | — | — | 1 | 6.17 |
| CHEMBL41113 | — | — | 1 | 6.12 |
| CHEMBL39596 | — | — | 1 | 5.79 |
| CHEMBL38569 | — | — | 1 | 5.79 |
| CHEMBL41948 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38538 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL38486 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL40966 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL284782 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL41113 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL39596 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL38569 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL41948 | — | EC50 | = | 2640.0 | nM | 5.58 |