Assay Detail
Binding
CHEMBL822640
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Inhibition of c-AMP dependent kinase (PKA) using histone II A protein
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Design and synthesis of new leads for PKC bisubstrate inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.88 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329274 | — | — | 1 | 5.70 |
| CHEMBL1233654 | — | — | 1 | 5.52 |
| CHEMBL100102 | — | — | 1 | 4.30 |
| CHEMBL97026 | — | — | 1 | 4.00 |
| CHEMBL327291 | — | — | 1 | - |
| CHEMBL97448 | — | — | 1 | - |
| CHEMBL99572 | — | — | 1 | - |
| CHEMBL95737 | — | — | 1 | - |
| CHEMBL318650 | — | — | 1 | - |
| CHEMBL95812 | — | — | 1 | - |
| CHEMBL97796 | — | — | 1 | - |
| CHEMBL97768 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329274 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1233654 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL100102 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL97026 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL327291 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL97448 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL99572 | — | IC50 | = | 210000.0 | nM | - |
| CHEMBL95737 | — | IC50 | = | 390000.0 | nM | - |
| CHEMBL318650 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL95812 | — | IC50 | = | 390000.0 | nM | - |
| CHEMBL97796 | — | IC50 | = | 310000.0 | nM | - |
| CHEMBL97768 | — | IC50 | = | 150000.0 | nM | - |