Assay Detail
Binding
CHEMBL822708
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Cardiotonic effect by inhibition of cAMP phosphodiesterase (PDE III)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Bipyridine cardiotonics: the three-dimensional structures of amrinone and milrinone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.69 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189 | MILRINONE | 4.0 | 1 | 4.92 |
| CHEMBL346320 | — | — | 1 | 4.92 |
| CHEMBL302219 | — | — | 1 | 4.51 |
| CHEMBL156746 | — | — | 1 | 4.42 |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | - |
| CHEMBL58782 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189 | MILRINONE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL346320 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL302219 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL156746 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL12856 | INAMRINONE | IC50 | = | 150000.0 | nM | - |
| CHEMBL58782 | — | IC50 | = | 380000.0 | nM | - |