Assay Detail
Binding
CHEMBL822770
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]nonpeptide ligand (compound 7) from purified human recombinant alphaV-beta3
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.32 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123262 | — | — | 1 | 10.15 |
| CHEMBL332914 | — | — | 1 | 10.10 |
| CHEMBL123374 | — | — | 1 | 9.36 |
| CHEMBL122000 | — | — | 1 | 9.03 |
| CHEMBL333019 | — | — | 1 | 7.97 |
| CHEMBL59562 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123262 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL332914 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL123374 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL122000 | — | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL333019 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL59562 | — | IC50 | > | 1000.0 | nM | - |