Assay Detail
Binding
CHEMBL822803
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Inhibition of c-Src-tyrosine kinase.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 4.92 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293991 | — | — | 1 | 6.30 |
| CHEMBL291963 | — | — | 1 | 5.80 |
| CHEMBL55379 | — | — | 1 | 5.66 |
| CHEMBL56359 | — | — | 1 | 5.52 |
| CHEMBL56669 | — | — | 1 | 5.43 |
| CHEMBL58436 | — | — | 1 | 5.31 |
| CHEMBL56904 | — | — | 1 | 5.11 |
| CHEMBL418270 | — | — | 1 | 5.05 |
| CHEMBL59099 | — | — | 1 | 5.01 |
| CHEMBL57553 | — | — | 1 | 4.85 |
| CHEMBL57443 | — | — | 1 | 4.80 |
| CHEMBL277931 | — | — | 1 | 4.80 |
| CHEMBL55742 | — | — | 1 | 4.36 |
| CHEMBL58142 | — | — | 1 | 4.34 |
| CHEMBL55592 | — | — | 1 | 4.11 |
| CHEMBL292866 | — | — | 1 | 4.05 |
| CHEMBL56671 | — | — | 1 | 4.05 |
| CHEMBL56081 | — | — | 1 | 4.03 |
| CHEMBL278103 | — | — | 1 | - |
| CHEMBL20926 | — | — | 1 | - |
| CHEMBL57690 | — | — | 1 | - |
| CHEMBL58580 | — | — | 1 | - |
| CHEMBL55662 | — | — | 1 | - |
| CHEMBL418010 | — | — | 1 | - |
| CHEMBL60816 | — | — | 1 | - |
| CHEMBL299707 | — | — | 1 | - |
| CHEMBL59036 | — | — | 1 | - |
| CHEMBL55683 | — | — | 1 | - |
| CHEMBL418279 | — | — | 1 | - |
| CHEMBL423288 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293991 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL291963 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL55379 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL56359 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL56669 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL58436 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL56904 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL418270 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL59099 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL57553 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL57443 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL277931 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL55742 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL58142 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL55592 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL292866 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL56671 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL56081 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL20867 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL941 | IMATINIB | IC50 | > | 100000.0 | nM | - |
| CHEMBL57581 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL21162 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL300817 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL57556 | — | IC50 | = | 126000.0 | nM | - |
| CHEMBL20252 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL423288 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL418279 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL55683 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL59036 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL299707 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL60816 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL418010 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL55662 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL58580 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL57690 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20926 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL278103 | — | IC50 | > | 100000.0 | nM | - |