Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL822804

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [32P]ATP incorporated (phosphorylation) into glutamate-tyrosine copolymer substrate by avian c-Src tyrosine kinase
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Proto-oncogene tyrosine-protein kinase Src (CHEMBL267)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relationships for 5-substituted 1-phenylbenzimidazoles as selective inhibitors of the platelet-derived growth factor receptor.
Palmer BD, Kraker AJ, Hartl BG, Panopoulos AD, Panek RL, Batley BL, Lu GH, Trumpp-Kallmeyer S, Showalter HD, Denny WA.
J Med Chem (1999) 42 : 2373 -2382
PubMed 10395478 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 4.57 6.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL77303 1 6.34
CHEMBL312269 1 4.85
CHEMBL77261 1 4.60
CHEMBL308245 1 4.60
CHEMBL75969 1 4.55
CHEMBL311574 1 4.48
CHEMBL77032 1 4.47
CHEMBL77412 1 4.40
CHEMBL79177 1 4.40
CHEMBL311449 1 4.30
CHEMBL80915 1 4.30
CHEMBL310726 1 4.30
CHEMBL77242 1 4.30
CHEMBL306184 1 4.30
CHEMBL78698 1 4.30
CHEMBL443800 1 -
CHEMBL309035 1 -
CHEMBL307817 1 -
CHEMBL309270 1 -
CHEMBL80810 1 -
CHEMBL80171 1 -
CHEMBL311777 1 -
CHEMBL308385 1 -
CHEMBL75637 1 -
CHEMBL310080 1 -
CHEMBL76839 1 -
CHEMBL78444 1 -
CHEMBL419653 1 -
CHEMBL76962 1 -
CHEMBL310137 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL77303 IC50 = 460.0 nM 6.34
CHEMBL312269 IC50 = 14000.0 nM 4.85
CHEMBL77261 IC50 = 25000.0 nM 4.60
CHEMBL308245 IC50 = 25000.0 nM 4.60
CHEMBL75969 IC50 = 28000.0 nM 4.55
CHEMBL311574 IC50 = 33300.0 nM 4.48
CHEMBL77032 IC50 = 33500.0 nM 4.47
CHEMBL77412 IC50 = 40000.0 nM 4.40
CHEMBL79177 IC50 = 40000.0 nM 4.40
CHEMBL80915 IC50 = 50000.0 nM 4.30
CHEMBL310726 IC50 = 50000.0 nM 4.30
CHEMBL77242 IC50 = 50000.0 nM 4.30
CHEMBL311449 IC50 = 50000.0 nM 4.30
CHEMBL306184 IC50 = 50000.0 nM 4.30
CHEMBL78698 IC50 = 50000.0 nM 4.30
CHEMBL77712 IC50 > 50000.0 nM -
CHEMBL79328 IC50 > 50000.0 nM -
CHEMBL80651 IC50 > 50000.0 nM -
CHEMBL76202 IC50 > 50000.0 nM -
CHEMBL80873 IC50 > 50000.0 nM -
CHEMBL80558 IC50 > 50000.0 nM -
CHEMBL311318 IC50 > 50000.0 nM -
CHEMBL75964 IC50 > 50000.0 nM -
CHEMBL310243 IC50 > 50000.0 nM -
CHEMBL311913 IC50 > 50000.0 nM -
CHEMBL80510 IC50 > 50000.0 nM -
CHEMBL443800 IC50 > 50000.0 nM -
CHEMBL309035 IC50 > 50000.0 nM -
CHEMBL307817 IC50 > 50000.0 nM -
CHEMBL309270 IC50 > 50000.0 nM -
CHEMBL80810 IC50 > 50000.0 nM -
CHEMBL80171 IC50 > 50000.0 nM -
CHEMBL311777 IC50 > 50000.0 nM -
CHEMBL308385 IC50 > 50000.0 nM -
CHEMBL75637 IC50 > 50000.0 nM -
CHEMBL310080 IC50 > 50000.0 nM -
CHEMBL76839 IC50 > 50000.0 nM -
CHEMBL78444 IC50 > 50000.0 nM -
CHEMBL419653 IC50 > 50000.0 nM -
CHEMBL76962 IC50 > 50000.0 nM -
CHEMBL310137 IC50 > 50000.0 nM -