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Assay Detail

CHEMBL822806

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of c-Src tyrosine kinase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Proto-oncogene tyrosine-protein kinase Src (CHEMBL267)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases.
Barvian M, Boschelli DH, Cossrow J, Dobrusin E, Fattaey A, Fritsch A, Fry D, Harvey P, Keller P, Garrett M, La F, Leopold W, McNamara D, Quin M, Trumpp-Kallmeyer S, Toogood P, Wu Z, Zhang E.
J Med Chem (2000) 43 : 4606 -4616
PubMed 11101352 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.68 4.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL142648 1 4.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL142648 IC50 = 21000.0 nM 4.68