Assay Detail
Binding
CHEMBL822980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of prostaglandin-F alkylphosphinic acid derivatives as bone anabolic agents for the treatment of osteoporosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.94 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334398 | — | — | 1 | 8.70 |
| CHEMBL815 | DINOPROST | 4.0 | 1 | 8.52 |
| CHEMBL440164 | — | — | 1 | 7.38 |
| CHEMBL134546 | — | — | 1 | 6.94 |
| CHEMBL336781 | — | — | 1 | 6.51 |
| CHEMBL133945 | — | — | 1 | 5.39 |
| CHEMBL133910 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334398 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL815 | DINOPROST | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL440164 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL134546 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL336781 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL133945 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL133910 | — | IC50 | = | 6700.0 | nM | 5.17 |