Assay Detail
Binding
CHEMBL823096
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]VCAM-Ig binding to human integrin alpha4-beta1 (VLA-4) of Jurkat cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-aryl-prolyl-dipeptides as potent antagonists of VLA-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 9.32 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69035 | — | — | 1 | 10.30 |
| CHEMBL305408 | — | — | 1 | 9.96 |
| CHEMBL70107 | — | — | 1 | 9.77 |
| CHEMBL69352 | — | — | 1 | 9.47 |
| CHEMBL307096 | — | — | 1 | 9.43 |
| CHEMBL367599 | — | — | 1 | 9.42 |
| CHEMBL308458 | — | — | 1 | 9.39 |
| CHEMBL69888 | — | — | 1 | 9.21 |
| CHEMBL68592 | — | — | 1 | 9.14 |
| CHEMBL71554 | — | — | 1 | 8.96 |
| CHEMBL71705 | — | — | 1 | 8.96 |
| CHEMBL422054 | — | — | 1 | 8.72 |
| CHEMBL71577 | — | — | 1 | 8.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69035 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL305408 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL70107 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL69352 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL307096 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL367599 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL308458 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL69888 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL68592 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL71554 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL71705 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL422054 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL71577 | — | IC50 | = | 3.2 | nM | 8.49 |