Assay Detail
Binding
CHEMBL823112
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Binding affinity of compound towards Vasopressin receptor by binding [3H]LVP to dog renal medullary preparation.
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Tissue | Renal medulla |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A minor modification of residue 1 in potent vasopressin antagonists dramatically reduces agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.96 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2371605 | — | — | 1 | 9.30 |
| CHEMBL2371604 | — | — | 1 | 9.15 |
| CHEMBL3084974 | — | — | 1 | 9.00 |
| CHEMBL262482 | — | — | 2 | 9.00 |
| CHEMBL438014 | — | — | 1 | 9.00 |
| CHEMBL384776 | — | — | 1 | 8.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2371605 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL2371604 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3084974 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL262482 | — | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL438014 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL384776 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL262482 | — | Ki | = | 4.9 | nM | 8.31 |