Assay Detail
Functional
CHEMBL823133
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibitory activity against human tumor cell line A549 (a non small, drug resistant cell line that does not produce P-glycoprotein) of lung carcinoma using sulforhodamine B assay.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Analogues of amonafide and azonafide with novel ring systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.99 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.52 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 8.00 |
| CHEMBL321274 | — | — | 1 | 7.89 |
| CHEMBL105650 | — | — | 1 | 7.75 |
| CHEMBL318380 | — | — | 1 | 7.66 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.66 |
| CHEMBL106541 | — | — | 1 | 7.50 |
| CHEMBL105801 | — | — | 1 | 7.50 |
| CHEMBL107783 | — | — | 1 | 7.43 |
| CHEMBL105797 | — | — | 1 | 7.35 |
| CHEMBL324189 | — | — | 1 | 6.82 |
| CHEMBL318355 | — | — | 1 | 6.81 |
| CHEMBL105443 | — | — | 1 | 6.80 |
| CHEMBL321071 | — | — | 1 | 6.77 |
| CHEMBL105615 | — | — | 1 | 6.77 |
| CHEMBL319702 | — | — | 1 | 6.66 |
| CHEMBL105266 | — | — | 1 | 6.66 |
| CHEMBL104820 | — | — | 1 | 6.55 |
| CHEMBL105503 | — | — | 1 | 6.38 |
| CHEMBL319187 | — | — | 1 | 6.12 |
| CHEMBL105277 | — | — | 1 | 6.07 |
| CHEMBL105035 | — | — | 1 | 6.06 |
| CHEMBL323455 | — | — | 1 | 6.02 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL321274 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL105650 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL318380 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL106541 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL105801 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL107783 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL105797 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL324189 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL318355 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL105443 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL321071 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL105615 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL319702 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL105266 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL104820 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL105503 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL319187 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL105277 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL105035 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL323455 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 1100.0 | nM | 5.96 |