Assay Detail
Functional
CHEMBL823136
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In Vitro cytotoxicity against human lung cancer cell line (H128)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H128 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.28 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.22 |
| CHEMBL289665 | — | — | 1 | 8.15 |
| CHEMBL297811 | — | — | 1 | 8.00 |
| CHEMBL44044 | — | — | 1 | 7.89 |
| CHEMBL445883 | — | — | 1 | 7.89 |
| CHEMBL296862 | — | — | 1 | 7.85 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.75 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.51 |
| CHEMBL288053 | — | — | 1 | 7.12 |
| CHEMBL41652 | — | — | 1 | 6.76 |
| CHEMBL290652 | — | — | 1 | 5.13 |
| CHEMBL297040 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL289665 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL297811 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL44044 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL445883 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL296862 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL288053 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL41652 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL290652 | — | IC50 | = | 7439.0 | nM | 5.13 |
| CHEMBL297040 | — | IC50 | = | 8500.0 | nM | 5.07 |