Assay Detail
Binding
CHEMBL823224
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p56 lck tyrosine kinase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: potent and selective inhibitors of ZAP 70.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.76 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112263 | — | — | 1 | 5.96 |
| CHEMBL113185 | — | — | 1 | 5.92 |
| CHEMBL112346 | — | — | 1 | 5.66 |
| CHEMBL322066 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112263 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL113185 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL112346 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL322066 | — | IC50 | = | 3300.0 | nM | 5.48 |