Assay Detail
Binding
CHEMBL823263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of a non-peptide radioligand from human recombinant alphaV-beta3 integrin
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.47 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300008 | — | — | 1 | 9.46 |
| CHEMBL329081 | — | — | 1 | 9.03 |
| CHEMBL416669 | — | — | 1 | 8.92 |
| CHEMBL53822 | — | — | 1 | 8.89 |
| CHEMBL95987 | — | — | 1 | 8.54 |
| CHEMBL95750 | — | — | 1 | 8.06 |
| CHEMBL99287 | — | — | 1 | 7.92 |
| CHEMBL82927 | — | — | 1 | 6.96 |
| CHEMBL100246 | — | — | 1 | - |
| CHEMBL313763 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300008 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL329081 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL416669 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL53822 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL95987 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL95750 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL99287 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL82927 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL100246 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL313763 | — | IC50 | > | 10000.0 | nM | - |