Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL823474

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Xanthine Oxidase
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Xanthine dehydrogenase/oxidase (CHEMBL1929)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of new imidazole, pyrimidine, and purine derivatives and analogs as inhibitors of xanthine oxidase.
Biagi G, Costantini A, Costantino L, Giorgi I, Livi O, Pecorari P, Rinaldi M, Scartoni V.
J Med Chem (1996) 39 : 2529 -2535
PubMed 8691450 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.28 6.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL86056 1 6.94
CHEMBL85737 1 5.96
CHEMBL83530 1 5.72
CHEMBL86021 1 5.54
CHEMBL84609 1 5.41
CHEMBL1467 ALLOPURINOL 4.0 1 5.38
CHEMBL84643 1 5.37
CHEMBL86311 1 4.90
CHEMBL305113 1 4.59
CHEMBL84310 1 4.55
CHEMBL64616 1 4.52
CHEMBL315735 1 4.44
CHEMBL86132 1 -
CHEMBL84620 1 -
CHEMBL314120 1 -
CHEMBL83516 1 -
CHEMBL85062 1 -
CHEMBL82756 1 -
CHEMBL84772 1 -
CHEMBL316254 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL86056 IC50 = 115.0 nM 6.94
CHEMBL85737 IC50 = 1110.0 nM 5.96
CHEMBL83530 IC50 = 1920.0 nM 5.72
CHEMBL86021 IC50 = 2850.0 nM 5.54
CHEMBL84609 IC50 = 3880.0 nM 5.41
CHEMBL1467 ALLOPURINOL IC50 = 4200.0 nM 5.38
CHEMBL84643 IC50 = 4290.0 nM 5.37
CHEMBL86311 IC50 = 12600.0 nM 4.90
CHEMBL305113 IC50 = 25500.0 nM 4.59
CHEMBL84310 IC50 = 28300.0 nM 4.55
CHEMBL64616 IC50 = 30500.0 nM 4.52
CHEMBL315735 IC50 = 36520.0 nM 4.44
CHEMBL86132 IC50 > 100000.0 nM -
CHEMBL84620 IC50 > 100000.0 nM -
CHEMBL314120 IC50 > 100000.0 nM -
CHEMBL83516 IC50 > 100000.0 nM -
CHEMBL85062 IC50 > 100000.0 nM -
CHEMBL82756 IC50 > 100000.0 nM -
CHEMBL84772 IC50 > 100000.0 nM -
CHEMBL316254 IC50 > 100000.0 nM -