Assay Detail
Binding
CHEMBL823497
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Inhibition of integrin alpha4-beta1 adhesion to Jurkat cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.80 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88478 | — | — | 1 | 8.40 |
| CHEMBL1791268 | — | — | 1 | 8.30 |
| CHEMBL369635 | — | — | 1 | 8.22 |
| CHEMBL173699 | — | — | 1 | 8.10 |
| CHEMBL275913 | — | — | 1 | 7.70 |
| CHEMBL353994 | — | — | 1 | 7.52 |
| CHEMBL173552 | — | — | 1 | 7.17 |
| CHEMBL64387 | — | — | 1 | 6.70 |
| CHEMBL354130 | — | — | 1 | 5.49 |
| CHEMBL368564 | — | — | 1 | 5.30 |
| CHEMBL355249 | — | — | 1 | 4.40 |
| CHEMBL173870 | — | — | 1 | 4.29 |
| CHEMBL172193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88478 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1791268 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL369635 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL173699 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL275913 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL353994 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL173552 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL64387 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL354130 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL368564 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL355249 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL173870 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL172193 | — | IC50 | = | 175000.0 | nM | - |