Assay Detail
Binding
CHEMBL823518
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for TS activity against human Thymidylate synthase by tight binding kinetics
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.40 | 9.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166027 | — | — | 1 | 9.91 |
| CHEMBL166369 | — | — | 1 | 8.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166027 | — | Ki | = | 0.124 | nM | 9.91 |
| CHEMBL166369 | — | Ki | = | 1.31 | nM | 8.88 |