Assay Detail
Functional
CHEMBL823526
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Inhibitory concentration against human adenocarcinoma HT-29 cell line under hypoxic condition
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.47 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53696 | — | — | 1 | 6.26 |
| CHEMBL50512 | — | — | 1 | 6.14 |
| CHEMBL50823 | — | — | 1 | 6.10 |
| CHEMBL299182 | — | — | 1 | 5.89 |
| CHEMBL53447 | — | — | 1 | 5.73 |
| CHEMBL53017 | — | — | 1 | 5.68 |
| CHEMBL53776 | — | — | 1 | 5.68 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 5.28 |
| CHEMBL53592 | — | — | 1 | 4.89 |
| CHEMBL52475 | — | — | 1 | 4.82 |
| CHEMBL301335 | — | — | 1 | 4.63 |
| CHEMBL301391 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53696 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL50512 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL50823 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL299182 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL53447 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL53017 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL53776 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL53592 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL52475 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL301335 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL301391 | — | IC50 | = | 28800.0 | nM | 4.54 |