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Assay Detail

CHEMBL823562

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Tested for inhibition of catalytic subunit of cAMP-dependent protein kinase from bovine heart
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Novel indolocarbazole protein kinase c inhibitors with improved biochemical and physicochemical properties
Kleinschroth J, Hartenstein J, Rudolph C, Schachtele C
Bioorg Med Chem Lett (1995) 5 : 55 -60
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.50 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL156433 1 6.70
CHEMBL345593 1 6.40
CHEMBL157822 1 6.29
CHEMBL155929 1 6.12
CHEMBL156172 1 5.20
CHEMBL157892 1 5.00
CHEMBL345639 1 4.82
CHEMBL346038 1 4.62
CHEMBL346467 1 4.35
CHEMBL348177 1 -
CHEMBL302449 GO-6976 1 -
CHEMBL154245 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL156433 IC50 = 200.0 nM 6.70
CHEMBL345593 IC50 = 400.0 nM 6.40
CHEMBL157822 IC50 = 510.0 nM 6.29
CHEMBL155929 IC50 = 750.0 nM 6.12
CHEMBL156172 IC50 = 6300.0 nM 5.20
CHEMBL157892 IC50 = 9900.0 nM 5.00
CHEMBL345639 IC50 = 15000.0 nM 4.82
CHEMBL346038 IC50 = 24000.0 nM 4.62
CHEMBL346467 IC50 = 45000.0 nM 4.35
CHEMBL348177 IC50 > 30000.0 nM -
CHEMBL302449 GO-6976 IC50 > 100000.0 nM -
CHEMBL154245 IC50 > 10000.0 nM -