Assay Detail
Binding
CHEMBL823581
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Inhibition of rat brain cytosolic cGMP phosphodiesterase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.20 | 4.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278972 | — | — | 1 | 4.33 |
| CHEMBL18262 | — | — | 1 | 4.24 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278972 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL18262 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL28079 | ZAPRINAST | IC50 | = | 93300.0 | nM | 4.03 |