Assay Detail
Binding
CHEMBL823582
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat brain particulate cGMP phosphodiesterase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL4650) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.15 | 4.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 4.20 |
| CHEMBL18262 | — | — | 1 | 4.10 |
| CHEMBL278972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28079 | ZAPRINAST | IC50 | = | 63100.0 | nM | 4.20 |
| CHEMBL18262 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL278972 | — | IC50 | = | 126000.0 | nM | - |