Assay Detail
Functional
CHEMBL823709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 45 [Ca2+] flux into rat brain synaptosomes depolarized by elevated potassium concentrations
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and characterization of N-(acenaphth-5-yl)-N'-(4-methoxynaphth-1-yl)guanidine as a glutamate release inhibitor and potential anti-ischemic agent
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.53 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28853 | — | — | 1 | 5.65 |
| CHEMBL28854 | SIPATRIGINE | 2.0 | 1 | 5.41 |
| CHEMBL744 | RILUZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28853 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL28854 | SIPATRIGINE | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL744 | RILUZOLE | IC50 | > | 30000.0 | nM | - |