Assay Detail
Functional
CHEMBL823923
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for functional activity against neuronal nicotinic acetylcholine receptor(nAChR) expressed in K177 cells using isotopic rubidium efflux assay.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K177 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907589) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Novel 2-(2-furo[3,2-b]pyridinyl) pyrrolidines: potent neuronal nicotinic acetylcholine receptor ligands
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.37 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84149 | — | — | 1 | 6.12 |
| CHEMBL93883 | — | — | 1 | 5.50 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 5.30 |
| CHEMBL274525 | ABT-418 | — | 1 | 4.97 |
| CHEMBL328323 | — | — | 1 | 4.96 |
| CHEMBL327441 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84149 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL93883 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3 | NICOTINE | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL274525 | ABT-418 | EC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL328323 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL327441 | — | EC50 | > | 1000000.0 | nM | - |