Assay Detail
Functional
CHEMBL823997
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity at kappa opioid receptor of rabbit vas deferens
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Vas deferens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Preparation and evaluation of some hydrophilic phenylacetyl-piperazines as peripherally selective -opioid receptor agonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.11 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277863 | — | — | 1 | 10.70 |
| CHEMBL423653 | — | — | 1 | 9.66 |
| CHEMBL279298 | — | — | 1 | 9.05 |
| CHEMBL23607 | — | — | 1 | 8.82 |
| CHEMBL22544 | — | — | 1 | 8.34 |
| CHEMBL276970 | — | — | 1 | 8.20 |
| CHEMBL23472 | ICI-204448 | — | 1 | 8.13 |
| CHEMBL23499 | — | — | 1 | 7.85 |
| CHEMBL277636 | — | — | 1 | 7.43 |
| CHEMBL25604 | — | — | 1 | 7.31 |
| CHEMBL23631 | — | — | 1 | 6.85 |
| CHEMBL23352 | — | — | 1 | 6.64 |
| CHEMBL23535 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277863 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL423653 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL279298 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL23607 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL22544 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL276970 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL23472 | ICI-204448 | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL23499 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL277636 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL25604 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL23631 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL23352 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL23535 | — | IC50 | = | 400.0 | nM | 6.40 |