Assay Detail
Binding
CHEMBL824029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: potent and selective inhibitors of ZAP 70.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.90 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112346 | — | — | 1 | 8.10 |
| CHEMBL325912 | — | — | 1 | 7.96 |
| CHEMBL112518 | — | — | 1 | 7.58 |
| CHEMBL112172 | — | — | 1 | 7.51 |
| CHEMBL420672 | — | — | 1 | 7.34 |
| CHEMBL322066 | — | — | 1 | 7.27 |
| CHEMBL113185 | — | — | 1 | 6.90 |
| CHEMBL419757 | — | — | 1 | 6.73 |
| CHEMBL112561 | — | — | 1 | 6.48 |
| CHEMBL323755 | — | — | 1 | 6.40 |
| CHEMBL324576 | — | — | 1 | 6.37 |
| CHEMBL112263 | — | — | 1 | 5.72 |
| CHEMBL112623 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112346 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL325912 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL112518 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL112172 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL420672 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL322066 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL113185 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL419757 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL112561 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL323755 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL324576 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL112263 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL112623 | — | IC50 | = | 4300.0 | nM | 5.37 |