Assay Detail
Functional
CHEMBL824052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration that causes inhibition of alpha-7 nAChR, was determined. Values are expressed as EC50 +/- SEM.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.00 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111583 | — | — | 1 | 6.55 |
| CHEMBL108799 | — | — | 1 | 6.24 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 5.89 |
| CHEMBL320963 | — | — | 1 | 5.32 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111583 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL108799 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL56564 | TROPISETRON | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL320963 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL667 | ACETYLCHOLINE | EC50 | = | 230000.0 | nM | - |