Assay Detail
Binding
CHEMBL824055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
binding affinity in rat hippocampi against alpha7 nicotinic receptor
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.41 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293975 | — | — | 2 | 7.04 |
| CHEMBL193016 | — | — | 1 | 6.72 |
| CHEMBL129932 | — | — | 3 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293975 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL193016 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL129932 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL129932 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL293975 | — | Ki | = | 9400.0 | nM | 5.03 |
| CHEMBL129932 | — | Ki | > | 32000.0 | nM | - |