Assay Detail
Binding
CHEMBL824059
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Inhibitory activity against human alpha V beta3 receptor using SPAV3 assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Non-peptide alphavbeta3 antagonists. Part 6: design and synthesis of alphavbeta3 antagonists containing a pyridone or pyrazinone central scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.83 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51391 | — | — | 1 | 9.70 |
| CHEMBL53003 | — | — | 1 | 9.70 |
| CHEMBL51152 | — | — | 1 | 9.70 |
| CHEMBL54148 | — | — | 1 | 9.52 |
| CHEMBL300008 | — | — | 1 | 9.40 |
| CHEMBL301131 | — | — | 1 | 9.15 |
| CHEMBL53503 | — | — | 1 | 8.96 |
| CHEMBL53822 | — | — | 1 | 8.89 |
| CHEMBL53122 | — | — | 1 | 8.85 |
| CHEMBL54259 | — | — | 1 | 8.72 |
| CHEMBL301301 | — | — | 1 | 8.68 |
| CHEMBL299110 | — | — | 1 | 8.57 |
| CHEMBL53145 | — | — | 1 | 8.03 |
| CHEMBL301282 | — | — | 1 | 7.68 |
| CHEMBL50698 | — | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51391 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL53003 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL51152 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL54148 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL300008 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL301131 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL53503 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL53822 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL53122 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL54259 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL301301 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL299110 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL53145 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL301282 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL50698 | — | IC50 | = | 112.0 | nM | 6.95 |