Assay Detail
Binding
CHEMBL824082
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Inhibition of vitronectin binding to recombinant human alphaV-beta5 integrin
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.33 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266151 | — | — | 1 | 7.58 |
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 7.43 |
| CHEMBL9278 | — | — | 1 | 7.41 |
| CHEMBL2372357 | — | — | 1 | 7.40 |
| CHEMBL9737 | — | — | 1 | 7.38 |
| CHEMBL9200 | — | — | 1 | 6.46 |
| CHEMBL2372407 | — | — | 1 | 6.27 |
| CHEMBL2372331 | — | — | 1 | 6.18 |
| CHEMBL417426 | — | — | 1 | 5.80 |
| CHEMBL268056 | — | — | 1 | 5.60 |
| CHEMBL9555 | — | — | 1 | 5.57 |
| CHEMBL267434 | — | — | 1 | 5.29 |
| CHEMBL9508 | — | — | 1 | 5.24 |
| CHEMBL417066 | — | — | 1 | 5.06 |
| CHEMBL2372398 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266151 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL429876 | CILENGITIDE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL9278 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2372357 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL9737 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL9200 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2372407 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2372331 | — | IC50 | = | 662.0 | nM | 6.18 |
| CHEMBL417426 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL268056 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL9555 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL267434 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL9508 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL417066 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL2372398 | — | IC50 | > | 10000.0 | nM | - |